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EGFR, TTF-1 and Mdm2 expression in stage III non-small cell lung cancer: a positive association.
- Source :
-
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2008 Oct; Vol. 62 (1), pp. 35-44. Date of Electronic Publication: 2008 Mar 19. - Publication Year :
- 2008
-
Abstract
- New biological factors have not been extensively studied in stage III NSCLC as yet. The aim of this retrospective study was to assess the association between the expression and the prognostic role on survival of four biological markers in stage III NSCLC. Clinical characteristics were retrieved from the patients charts. EGF-R, Mdm2, p53 and TTF-1 expressions were evaluated by immunohistochemistry by three independent observers. Cox multivariate model was used to assess the impact of clinical and biological factors on patients' survival. A total of 84 stage III NSCLC patients, treated between 03/1987 and 08/2003, were included in the study. There was a statistically significant association between the expression of TTF-1 and EGFR (p=0.01) or TTF-1 and Mdm2 (p=0.04). Positive expressions for EGFR or TTF-1 were almost mutually exclusive. The status EGFR+/TTF-1--was mainly found in squamous cell carcinoma (18 among 19tumours). In multivariate analysis, only treatment with curative intent was independently associated with better survival (p=0.0004). In stage III NSCLC, there was a significant association between TTF-1 and EGFR or TTF-1 and Mdm2. The status EGFR+/TTF-1--was associated with squamous cell carcinoma.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung mortality
Carcinoma, Non-Small-Cell Lung pathology
Female
Humans
Immunohistochemistry
Lung Neoplasms mortality
Lung Neoplasms pathology
Male
Middle Aged
Prognosis
Retrospective Studies
Survival Analysis
Transcription Factors
Biomarkers, Tumor analysis
Carcinoma, Non-Small-Cell Lung metabolism
DNA-Binding Proteins biosynthesis
ErbB Receptors biosynthesis
Lung Neoplasms metabolism
Proto-Oncogene Proteins c-mdm2 biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0169-5002
- Volume :
- 62
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Lung cancer (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 18355939
- Full Text :
- https://doi.org/10.1016/j.lungcan.2008.02.003