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Expression of gamma delta T lymphocytes derived from human intestinal biopsies.
- Source :
-
Immunologic research [Immunol Res] 1991; Vol. 10 (3-4), pp. 310-2. - Publication Year :
- 1991
-
Abstract
- Although most T cells express the alpha/beta TCR, the gamma/delta TCR is expressed only on a small percentage of peripheral lymphocytes and CD3+ intestinal T cells. The most striking feature is a wide variation in the proportion of gamma/delta+ T cells in freshly isolated peripheral blood cells from normal individuals and patients with IBD. The augmentation of the gamma/delta+ T cell subpopulation derived from human intestinal biopsies after repeated stimulation with MT, even in the absence of filler cells, suggests that gamma/delta+ cells from human gut mucosa may play a role in generating a primary immune response to MT.
- Subjects :
- Cell Separation
Cells, Cultured
Humans
Inflammatory Bowel Diseases immunology
Inflammatory Bowel Diseases pathology
Mycobacterium tuberculosis immunology
Phytohemagglutinins immunology
Intestinal Mucosa cytology
Intestinal Mucosa immunology
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocytes cytology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0257-277X
- Volume :
- 10
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Immunologic research
- Publication Type :
- Academic Journal
- Accession number :
- 1835484
- Full Text :
- https://doi.org/10.1007/BF02919713