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Teicoplanin in perspective. A critical comparison with vancomycin.
- Source :
-
Pharmaceutisch weekblad. Scientific edition [Pharm Weekbl Sci] 1991 Aug 23; Vol. 13 (4), pp. 153-60. - Publication Year :
- 1991
-
Abstract
- Teicoplanin is a new glycopeptide antibiotic with a chemical structure related to vancomycin. The proposed advantages of teicoplanin over vancomycin are discussed. These include lower incidence of side-effects, lower toxicity (especially in combination with aminoglycosides), lower dosage frequency and the possibility of intramuscular administration. There is only a limited number of studies comparing both agents; more studies are still needed before firm conclusions can be drawn. Therapeutic drug monitoring is not usually necessary for teicoplanin; the situation is not clear for vancomycin. There is some doubt whether the incidence of resistance is as infrequent for teicoplanin as it is for vancomycin. Teicoplanin appears to be a promising alternative to vancomycin, but more data are needed on the relative clinical efficacy and the development of resistance to both drugs.
Details
- Language :
- English
- ISSN :
- 0167-6555
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pharmaceutisch weekblad. Scientific edition
- Publication Type :
- Academic Journal
- Accession number :
- 1834985
- Full Text :
- https://doi.org/10.1007/BF01957739