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High-titer collapsin response-mediating protein-associated (CRMP-5) paraneoplastic optic neuropathy and Vitritis as the only clinical manifestations in a patient with small cell lung carcinoma.
- Source :
-
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society [J Neuroophthalmol] 2008 Mar; Vol. 28 (1), pp. 17-22. - Publication Year :
- 2008
-
Abstract
- Paraneoplastic optic neuropathy (PON) is a rare syndrome usually associated with small cell lung carcinoma. In the 27 rigorously reported cases, neurologic manifestations other than visual loss have been present in all but 2. In the single case in which vision improved in response to treatment of the cancer, the collapsin response-mediating protein (CRMP)-5 titer did not change, and the ophthalmic examination was not detailed. We describe a patient with optic neuropathy and vitritis as the only clinical manifestations of PON marked by an extremely high titer of CRMP-5 antibody. Treatment of the underlying small cell lung cancer coincided with resolution of the visual abnormalities and a dramatic decrease in the CRMP-5 titer.
- Subjects :
- Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers, Tumor analysis
Biomarkers, Tumor blood
Biomarkers, Tumor immunology
Carcinoma, Small Cell radiotherapy
Female
Humans
Hydrolases
Lung pathology
Lung Neoplasms radiotherapy
Lymph Nodes pathology
Microtubule-Associated Proteins
Nerve Tissue Proteins analysis
Neural Cell Adhesion Molecules analysis
Neural Cell Adhesion Molecules metabolism
Optic Disk immunology
Optic Disk pathology
Optic Disk physiopathology
Optic Nerve Diseases blood
Optic Nerve Diseases immunology
Paraneoplastic Syndromes, Nervous System blood
Paraneoplastic Syndromes, Nervous System physiopathology
Radiotherapy
Retinal Artery immunology
Retinal Artery pathology
Retinal Artery physiopathology
Tomography, X-Ray Computed
Treatment Outcome
Up-Regulation drug effects
Up-Regulation immunology
Vision, Low blood
Vision, Low immunology
Vitreous Body immunology
Vitreous Body pathology
Vitreous Body physiopathology
Carcinoma, Small Cell complications
Lung Neoplasms complications
Nerve Tissue Proteins blood
Optic Nerve Diseases pathology
Paraneoplastic Syndromes, Nervous System pathology
Vision, Low pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5166
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
- Publication Type :
- Academic Journal
- Accession number :
- 18347453
- Full Text :
- https://doi.org/10.1097/WNO.0b013e3181675479