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Investigating biological activity spectrum for novel quinoline analogues 2: hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 Apr 15; Vol. 16 (8), pp. 4490-9. Date of Electronic Publication: 2008 Feb 23. - Publication Year :
- 2008
-
Abstract
- Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The compounds lipophilicity was determined by the RP-HPLC method. Several compounds showed biological activity similar or even higher than that of the standard (DCMU). The structure-activity relationships are discussed.
- Subjects :
- Chlorella vulgaris drug effects
Chlorella vulgaris metabolism
Chlorophyll metabolism
Chloroplasts drug effects
Hydrophobic and Hydrophilic Interactions
Hydroxyquinolines chemistry
Lipids chemistry
Molecular Structure
Photosynthesis
Spinacia oleracea drug effects
Structure-Activity Relationship
Amides chemistry
Hydroxyquinolines chemical synthesis
Hydroxyquinolines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18342517
- Full Text :
- https://doi.org/10.1016/j.bmc.2008.02.065