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Effect of ultrasonic debridement using a chlorhexidine irrigant on circulating levels of lipopolysaccharides and interleukin-6.
- Source :
-
Journal of clinical periodontology [J Clin Periodontol] 2008 May; Vol. 35 (5), pp. 415-9. Date of Electronic Publication: 2008 Mar 13. - Publication Year :
- 2008
-
Abstract
- Aim: Transient bacteraemia and endotoxaemia, and elevated levels of systemic cytokines have been reported following subgingival debridement. This study aimed to investigate the effect of chlorhexidine (CHX) solution on circulating levels of lipopolysaccharide (LPS) and interleukin-6 (IL-6) when used as an irrigant during ultrasonic debridement in patients with periodontitis.<br />Material and Methods: Eighteen patients with moderate to advanced chronic periodontitis were treated in a split-mouth, crossover, single-masked study. Irrigation with 0.02% CHX solution or water was used during treatment of two ipsilateral quadrants on two separate occasions 7 days apart, randomized as to order. Peripheral blood samples were collected for circulating levels of LPS and IL-6 at baseline, 5 and 120 min. after instrumentation commenced.<br />Results: Median concentrations of LPS were elevated from baseline to 5 min. into treatment with both CHX and control irrigant (p<0.05). Median levels of IL-6 increased with both treatments from baseline to 120 min. (p<0.001): CHX, 0.81-1.85 pg/ml; control, 0.78-1.78 EU/ml.<br />Conclusions: Ultrasonic instrumentation in patients with moderate to advanced periodontitis increases circulating levels of LPS after 5 min. and IL-6 120 min. after commencement of treatment, and is not affected by using 0.02% CHX as an irrigant instead of water.
- Subjects :
- Adult
Chronic Disease
Cross-Over Studies
Female
Humans
Interleukin-6 blood
Lipopolysaccharides blood
Male
Matched-Pair Analysis
Prospective Studies
Single-Blind Method
Therapeutic Irrigation
Anti-Infective Agents, Local therapeutic use
Chlorhexidine therapeutic use
Dental Scaling methods
Periodontitis blood
Periodontitis therapy
Ultrasonic Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1600-051X
- Volume :
- 35
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of clinical periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 18341600
- Full Text :
- https://doi.org/10.1111/j.1600-051X.2008.01221.x