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Comparison of the acute hemodynamic and coronary vasodilating effects between nicorandil and glyceryl trinitrate.
- Source :
-
Arzneimittel-Forschung [Arzneimittelforschung] 1991 Jun; Vol. 41 (6), pp. 591-4. - Publication Year :
- 1991
-
Abstract
- Acute hemodynamic and coronary vasodilating effects of nicorandol (SG-75, Sigmat; CAS 65141-46-0) and glyceryl trinitrate (GTN, nitroglycerin) were examined in 20 subjects under cardiac catheterization and coronary arteriography. Nicorandil 4 mg i.v. produced significant increases in heart rate, cardiac index and stroke volume index and significant decreases in systolic, diastolic and mean blood pressure, pulmonary capillary wedge pressure, left ventricular enddiastolic pressure, systemic vascular resistance and total pulmonary resistance. Degree of percent changes in these parameters by nicorandil were similar to that by GTN 0.3 mg i.v. Coronary vasodilating effects of both drugs were also at the same degree. Results indicate that nicorandil has cardiovascular and coronary vasodilating effects similar to those of GTN when administered intravenously.
- Subjects :
- Adult
Blood Pressure drug effects
Cardiac Output drug effects
Female
Heart Rate drug effects
Humans
Male
Middle Aged
Niacinamide pharmacology
Nicorandil
Pulmonary Circulation drug effects
Stroke Volume drug effects
Vascular Resistance drug effects
Coronary Circulation drug effects
Hemodynamics drug effects
Niacinamide analogs & derivatives
Nitroglycerin pharmacology
Vasodilation drug effects
Vasodilator Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0004-4172
- Volume :
- 41
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Arzneimittel-Forschung
- Publication Type :
- Academic Journal
- Accession number :
- 1834065