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Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: analysis of a series of 432 patients.
- Source :
-
Blood [Blood] 2008 May 15; Vol. 111 (10), pp. 5130-41. Date of Electronic Publication: 2008 Mar 12. - Publication Year :
- 2008
-
Abstract
- Limited knowledge exists about the impact of specific genetic abnormalities on the proliferation of neoplastic B cells from chronic lymphoproliferative disorders (B-CLPDs). Here we analyze the impact of cytogenetic abnormalities on the proliferation of neoplastic B cells in 432 B-CLPD patients, grouped according to diagnosis and site of sampling, versus their normal counterparts. Overall, proliferation of neoplastic B cells highly varied among the different B-CLPD subtypes, the greatest numbers of proliferating cells being identified in diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Compared with normal B cells, neoplastic B-CLPD cells showed significantly increased S + G(2)/M-phase values in mantle cell lymphoma (MCL), B-chronic lymphocytic leukemia (B-CLL), BL, and some DLBCL cases. Conversely, decreased proliferation was observed in follicular lymphoma, lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM), and some DLBCL patients; hairy cell leukemia, splenic marginal zone, and MALT-lymphoma patients showed S + G(2)/M phase values similar to normal mature B lymphocytes from LN. Interestingly, in B-CLL and MCL significantly higher percentages of S + G(2)/M cells were detected in BM versus PB and in LN versus BM and PB samples, respectively. In turn, presence of 14q32.3 gene rearrangements and DNA aneuploidy, was associated with a higher percentage of S + G(2)/M-phase cells among LPL/WM and B-CLL cases, respectively.
- Subjects :
- Adult
Aged
Aged, 80 and over
Aneuploidy
Female
Humans
Interphase
Kinetics
Lymphoproliferative Disorders diagnosis
Lymphoproliferative Disorders epidemiology
Lymphoproliferative Disorders genetics
Male
Middle Aged
B-Lymphocytes pathology
Cell Proliferation
Chromosome Aberrations
Lymphoproliferative Disorders pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 111
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 18337555
- Full Text :
- https://doi.org/10.1182/blood-2007-10-119289