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New steroidal derivatives synthesized using 3beta-hydroxyandrosten-17-one as starting material.
- Source :
-
Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2008 Mar; Vol. 58 (1), pp. 43-59. - Publication Year :
- 2008
-
Abstract
- In this study, we synthesized some new substituted steroidal derivatives using 3beta-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD50) of synthesized compounds are reported.
- Subjects :
- Anabolic Agents chemistry
Anabolic Agents pharmacology
Androgens chemistry
Androgens pharmacology
Androstanols chemistry
Androstanols pharmacology
Androstanols toxicity
Androstenes chemistry
Androstenes pharmacology
Androstenes toxicity
Animals
Dehydroepiandrosterone chemistry
Drug Evaluation, Preclinical
Genitalia, Male drug effects
Lethal Dose 50
Male
Molecular Structure
Muscles drug effects
Organ Size
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
Anabolic Agents chemical synthesis
Androgens chemical synthesis
Androstanols chemical synthesis
Androstenes chemical synthesis
Dehydroepiandrosterone analogs & derivatives
Drug Design
Subjects
Details
- Language :
- English
- ISSN :
- 1846-9558
- Volume :
- 58
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta pharmaceutica (Zagreb, Croatia)
- Publication Type :
- Academic Journal
- Accession number :
- 18337207
- Full Text :
- https://doi.org/10.2478/v10007-007-0044-2