Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors.

Authors :: Wyles DL
Kaihara KA
Schooley RT
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2008 May; Vol. 52 (5), pp. 1862-4. Date of Electronic Publication: 2008 Mar 10.
Publication Year :: 2008
Abstract: Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside and nonnucleoside polymerase inhibitors.

Subjects :: Antiviral Agents chemistry
Cell Line, Tumor
Drug Resistance, Viral
Drug Synergism
Humans
Molecular Structure
Phenylthiourea analogs & derivatives
Phenylthiourea chemistry
Phenylthiourea pharmacology
Protease Inhibitors chemistry
Antiviral Agents pharmacology
Hepacivirus drug effects
Protease Inhibitors pharmacology
RNA-Dependent RNA Polymerase antagonists & inhibitors
Viral Nonstructural Proteins antagonists & inhibitors

Full Text Access

Tools