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A small molecule inhibitor of alpha4 integrin-dependent cell migration.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2009 Feb 01; Vol. 17 (3), pp. 977-80. Date of Electronic Publication: 2008 Feb 26. - Publication Year :
- 2009
-
Abstract
- A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases.
- Subjects :
- Actinin antagonists & inhibitors
Actinin metabolism
Adenosine Kinase antagonists & inhibitors
Adenosine Kinase metabolism
Aniline Compounds chemical synthesis
Aniline Compounds chemistry
Animals
CHO Cells
Cell Line, Tumor
Cricetinae
Cricetulus
Humans
Integrin alpha4 drug effects
Jurkat Cells
RNA Interference
Signal Transduction
Small Molecule Libraries
Tubercidin chemical synthesis
Tubercidin chemistry
Tubercidin pharmacology
Aniline Compounds pharmacology
Cell Movement drug effects
Integrin alpha4 metabolism
Tubercidin analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18329275
- Full Text :
- https://doi.org/10.1016/j.bmc.2008.02.067