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Bortezomib, doxorubicin and dexamethasone in advanced multiple myeloma.
- Source :
-
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2008 Jun; Vol. 19 (6), pp. 1160-5. Date of Electronic Publication: 2008 Mar 06. - Publication Year :
- 2008
-
Abstract
- Background: Bortezomib has shown significant activity in myeloma. In this multicenter trial, we assessed for the first time the combination of bortezomib, doxorubicin and low-dose dexamethasone (PAd) in the treatment of relapsed/refractory myeloma.<br />Patients and Methods: Sixty-four patients were treated for a median of four 28-day cycles (1-6). Bortezomib was given at 1.3 mg/m(2) (days 1, 4, 8, 11) and dexamethasone at 40 mg (days 1-4); 34 patients receive doxorubicin at 20 mg/m(2) (days 1, 4) while 30 patients pegylated liposomal doxorubicin at 30 mg/m(2) (day 1).<br />Results: Fifty-eight percent of patients had undergone prior autologous transplantation, 70% prior anthracycline and 27% prior bortezomib-based regimens. Forty-three patients (67%) achieved at least a partial response including 16 (25%) with at least a very good partial response. One-year event-free survival was 34% after PAd and 31% after the previous line of therapy (hazard ratio 1.20, 95% confidence interval 0.76-1.90, P = 0.43). One-year overall survival from the start of PAd was 66%. Grade 3-4 toxic effects included thrombocytopenia (48%), neutropenia (36%), infections (15%), anemia (13%), gastrointestinal disturbances (11%) and peripheral neuropathy (10%). Two patients had grade 3-4 cardiac heart failure.<br />Conclusions: PAd is an active salvage therapy with manageable toxicity in patients with relapsed/refractory myeloma.
- Subjects :
- Adult
Aged
Aged, 80 and over
Boronic Acids administration & dosage
Bortezomib
Dexamethasone administration & dosage
Doxorubicin administration & dosage
Female
Humans
Male
Middle Aged
Multiple Myeloma pathology
Pyrazines administration & dosage
Salvage Therapy
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Multiple Myeloma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1569-8041
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of oncology : official journal of the European Society for Medical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 18326520
- Full Text :
- https://doi.org/10.1093/annonc/mdn018