Back to Search
Start Over
Atrial natriuretic factor after dopamine infusion in healthy subjects and in congestive heart failure.
- Source :
-
European heart journal [Eur Heart J] 1991 Jul; Vol. 12 (7), pp. 803-6. - Publication Year :
- 1991
-
Abstract
- We evaluated the effects of dopamine (DA) infusion (1.5 micrograms.kg-1.min-1 for 60 min) on secretion of atrial natriuretic factor (ANF) in 10 healthy subjects and 10 patients with congestive heart failure (CHF) (NYHA Classes III and IV). During DA infusion plasma levels of ANF were significantly raised in healthy subjects while the high basal values of ANF in CHF patients were significantly reduced; this trend was also evident for plasma noradrenaline (NA) levels in both groups. Diuresis, natriuresis and glomerular filtration rate were significantly increased while blood pressure, heart rate and central venous pressure remained unchanged in both groups. These findings indicate that DA infusion may affect the release of ANF. Changes in plasma NA concentration suggest that the sympathetic nervous system may be involved in this phenomenon.
- Subjects :
- Adult
Aged
Aldosterone blood
Blood Pressure drug effects
Diuresis drug effects
Female
Glomerular Filtration Rate drug effects
Heart Failure physiopathology
Heart Rate drug effects
Humans
Infusions, Parenteral
Male
Middle Aged
Norepinephrine blood
Renin blood
Vasopressins blood
Atrial Natriuretic Factor blood
Dopamine pharmacology
Heart Failure blood
Subjects
Details
- Language :
- English
- ISSN :
- 0195-668X
- Volume :
- 12
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 1832381