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Specific pathogen-free macaques: definition, history, and current production.
- Source :
-
ILAR journal [ILAR J] 2008; Vol. 49 (2), pp. 137-44. - Publication Year :
- 2008
-
Abstract
- Specific pathogen-free (SPF) macaque colonies are now requested frequently as a resource for research. Such colonies were originally conceived as a means to cull diseased animals from research-dedicated colonies, with the goal of eliminating debilitating or fatal infectious agents from the colony to improve the reproductive capacity of captive research animals. The initial pathogen of concern was Mycobacterium tuberculosis (M.tb.), recognized for many years as a pathogen of nonhuman primates as well as a human health target. More recently attention has focused on four viral pathogens as the basis for an SPF colony: simian type D retrovirus (SRV), simian immunodeficiency virus (SIV), simian T cell lymphotropic/leukemia virus (STLV), and Cercopithecine herpesvirus 1 (CHV-1). New technologies, breeding, and maintenance schemes have emerged to develop and provide SPF primates for research. In this review we focus on the nonhuman primates (NHPs) most common to North American NHP research facilities, Asian macaques, and the most common current research application of these animals, modeling of human AIDS.
- Subjects :
- Animals
Herpesvirus 1, Cercopithecine growth & development
Herpesvirus 1, Cercopithecine immunology
Macaca microbiology
Macaca virology
Mycobacterium tuberculosis growth & development
Mycobacterium tuberculosis immunology
Simian Immunodeficiency Virus growth & development
Simian Immunodeficiency Virus immunology
Simian T-lymphotropic virus 1 growth & development
Simian T-lymphotropic virus 1 immunology
Macaca blood
Specific Pathogen-Free Organisms
Subjects
Details
- Language :
- English
- ISSN :
- 1084-2020
- Volume :
- 49
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- ILAR journal
- Publication Type :
- Academic Journal
- Accession number :
- 18323576
- Full Text :
- https://doi.org/10.1093/ilar.49.2.137