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Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel.
- Source :
-
Equine veterinary journal [Equine Vet J] 2008 Jun; Vol. 40 (4), pp. 326-31. - Publication Year :
- 2008
-
Abstract
- Reasons for Performing Study: Increased plasma (5-HT) concentrations are reported in horses predisposed to develop laminitis and after i.v. infusion of endotoxins. In the equine jejunum contractile 5-HT1A-like receptors show tachyphylaxia upon prolonged activation with 5-HT. Therefore, increased systemic 5-HT release in colic horses could play a possible role in the pathophysiology of ileus.<br />Objective: To investigate possible increased systemic release of 5-HT in colic horses with compromised bowel and to identify the source of 5-HT overload.<br />Methods: Concentrations of 5-HT were determined in plasma and peritoneal fluid (PF) of healthy horses (n = 10), strangulating small intestinal colic horses (n = 18), nonsurgical colic horses (n = 10) and cryptorchid stallions (n = 6). It was attempted to identify the source of 5-HT overload by comparing the blood and PF 5-HT concentrations within horses and by assessing the in vivo platelet activation through determination of the beta-thromboglobulin (beta-TG)/platelet factor 4 (PF4) ratio.<br />Results: All horses in the strangulating small intestinal colic group had plasma (P = 0.006) and PF (P = 0.01) 5-HT concentrations above those found in the control group. Plasma beta-TG/PF4 ratio in these horses exceeded 2 in all cases, indicating in vivo platelet activation. Concentrations of 5-HT in PF of colic horses with compromised bowel were significantly lower than the corresponding plasma concentrations (P = 0.005).<br />Potential Relevance: In horses with compromised bowel, significant amounts of 5-HT can be released into the systemic circulation, through massive release of platelet-stored 5-HT. 5-HT is a very potent proinflammatory, vasoconstrictive and immunomodulatory agent. In view of the rapid and prolonged tachyphylaxia, shown for the jejunal 5-HT1A-like receptors, this increased systemic 5-HT release could play a role in the pathophysiology of ileus in horses.
- Subjects :
- Animals
Ascitic Fluid metabolism
Biomarkers blood
Biomarkers metabolism
Case-Control Studies
Colic blood
Colic metabolism
Colic surgery
Female
Horse Diseases blood
Horse Diseases surgery
Horses
Ileus blood
Ileus metabolism
Ileus surgery
Male
Platelet Activation
Postoperative Complications veterinary
Serotonin blood
Ascitic Fluid chemistry
Colic veterinary
Horse Diseases metabolism
Ileus veterinary
Serotonin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0425-1644
- Volume :
- 40
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Equine veterinary journal
- Publication Type :
- Academic Journal
- Accession number :
- 18321805
- Full Text :
- https://doi.org/10.2746/042516408X293583