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Increased vascular-endothelial growth factor (VEGF) tumor expression and response to epidermal growth factor receptor (EGF-R) inhibitor erlotinib in non-small cell lung cancer (NSCLC).
- Source :
-
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2008 Mar; Vol. 3 (3), pp. 314-6. - Publication Year :
- 2008
-
Abstract
- A 37-year-old female never smoker with metastatic large cell carcinoma of the lung had a partial response to a second line palliative therapy with the EGF-R tyrosine kinase inhibitor erlotinib after platinum based first line therapy failed. Molecular analysis of the primary and a liver metastasis did neither find any EGF-R mutation nor an EGF-R amplification. However, both the primary and the metastasis showed an increased gene expression of vascular-endothelial growth factor-A in contrast to normal tissue, which was confirmed by immunohistochemistry. To our knowledge, this is the first report about a high vascular-endothelial growth factor-A expression in the tumor of a patient responding to an EGF-R inhibitor postulating that there might be a link between both tyrosine kinase pathways.
- Subjects :
- Adult
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Non-Small-Cell Lung secondary
ErbB Receptors biosynthesis
ErbB Receptors genetics
Erlotinib Hydrochloride
Fatal Outcome
Female
Follow-Up Studies
Humans
Liver Neoplasms diagnosis
Liver Neoplasms metabolism
Liver Neoplasms secondary
Lung Neoplasms diagnosis
Lung Neoplasms drug therapy
Mutation
Protein Kinase Inhibitors therapeutic use
Retrospective Studies
Vascular Endothelial Growth Factor A biosynthesis
Carcinoma, Non-Small-Cell Lung metabolism
DNA, Neoplasm genetics
ErbB Receptors antagonists & inhibitors
Gene Expression Regulation, Neoplastic drug effects
Lung Neoplasms metabolism
Quinazolines therapeutic use
Vascular Endothelial Growth Factor A genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1556-1380
- Volume :
- 3
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 18317076
- Full Text :
- https://doi.org/10.1097/JTO.0b013e3181654423