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Thrombopoietin levels increased in patients with severe acute respiratory syndrome.
- Source :
-
Thrombosis research [Thromb Res] 2008; Vol. 122 (4), pp. 473-7. Date of Electronic Publication: 2008 Mar 07. - Publication Year :
- 2008
-
Abstract
- Hematological changes in patients with Severe Acute Respiratory Syndrome (SARS) are common and frequently include thrombocytopenia. Using a ELISA method, we found an increase in thrombopoietin (TPO) levels in the plasma of convalesced SARS patients (290+/-53 pg/ml) and active SARS patients (251+/-23 pg/ml) comparing to that from normal control patients (228+/-17 pg/ml). In addition, the plasma from active SARS patients had an inhibitory effect on CFU-MK formation, which could be neutralized by anti-TGF-beta antibodies. In the experiment to determine whether SARS-CoV can directly infect hematopoietic stem cells and megakaryocytic cells, incubation of the cells with SARS-CoV did not show active infection. Our findings of increased TPO levels in the plasma of SARS patients provide a possible explanation for the genesis of thrombocytosis, which frequently develops from thrombocytopenia in SARS patients.
- Subjects :
- Antigens, CD34 biosynthesis
Enzyme-Linked Immunosorbent Assay methods
Hematopoietic Stem Cells cytology
Humans
Megakaryocytes cytology
Microscopy, Fluorescence
Models, Biological
Regression Analysis
Severe acute respiratory syndrome-related coronavirus metabolism
Severe Acute Respiratory Syndrome virology
Stem Cells
Thrombocytopenia blood
Thrombocytopenia genetics
Transforming Growth Factor beta immunology
Gene Expression Regulation
Severe Acute Respiratory Syndrome blood
Thrombopoietin biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0049-3848
- Volume :
- 122
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Thrombosis research
- Publication Type :
- Academic Journal
- Accession number :
- 18314161
- Full Text :
- https://doi.org/10.1016/j.thromres.2007.12.021