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A high-throughput approach towards a novel formulation of fenofibrate in omega-3 oil.
- Source :
-
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2008 Apr 23; Vol. 33 (4-5), pp. 351-60. Date of Electronic Publication: 2008 Jan 21. - Publication Year :
- 2008
-
Abstract
- A novel lipid formulation containing fenofibrate in omega-3 oil was developed using a novel high-throughput screening platform. The optimized formulation combines the cardiovascular health benefits from omega-3 oil with the potent lipid-regulating effect of fenofibrate. When tested against the current marketed product Tricor in healthy human volunteers, the new formulation was shown to be equivalent to Tricor.
- Subjects :
- Administration, Oral
Area Under Curve
Chemistry, Pharmaceutical instrumentation
Cross-Over Studies
Drug Stability
Emulsions
Excipients chemistry
Fatty Acids, Omega-3 administration & dosage
Fatty Acids, Omega-3 pharmacokinetics
Fenofibrate administration & dosage
Fenofibrate pharmacokinetics
Half-Life
Humans
Hypolipidemic Agents administration & dosage
Hypolipidemic Agents pharmacokinetics
Molecular Structure
Solubility
Chemistry, Pharmaceutical methods
Drug Delivery Systems
Fatty Acids, Omega-3 chemistry
Fenofibrate chemistry
Hypolipidemic Agents chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0928-0987
- Volume :
- 33
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 18313905
- Full Text :
- https://doi.org/10.1016/j.ejps.2008.01.005