Back to Search
Start Over
The effect of ultralow-dose transdermal estradiol on sexual function in postmenopausal women.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2008 Mar; Vol. 198 (3), pp. 265.e1-7. - Publication Year :
- 2008
-
Abstract
- Objective: This study was undertaken to examine the effect of ultralow-dose transdermal estradiol on sexual function in postmenopausal women.<br />Study Design: Analysis of data from a multicenter, randomized, double-blind, placebo-controlled trial of a 0.014 mg/day transdermal estradiol patch in 417 women aged 60 to 80 years. Sexual function was assessed by self-administered questionnaires at baseline and 4, 12, and 24 months. A linear effects model was used to assess treatment effects using data from all on-study assessments.<br />Results: Women randomly assigned to estradiol had a 4.3 point greater improvement in the vaginal pain/dryness domain relative to placebo (95% CI = 0.3-8.4, P = .04). No significant differences in frequency of sexual activity or other sexual function domains (desire, satisfaction, problems, or orgasm) were observed between treatment groups (P > or = .10 for all).<br />Conclusions: Ultralow-dose estradiol resulted in modest improvement in sexual function related to vaginal pain and dryness, but not in other domains of sexual function.
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 198
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 18313446
- Full Text :
- https://doi.org/10.1016/j.ajog.2007.09.039