Screening for cytotoxic activity of extracts and isolated alkaloids from bulbs of Hippeastrum vittatum.

Authors :: Silva AF
de Andrade JP
Machado KR
Rocha AB
Apel MA
Sobral ME
Henriques AT
Zuanazzi JA
Source :: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2008 Oct; Vol. 15 (10), pp. 882-5. Date of Electronic Publication: 2008 Mar 04.
Publication Year :: 2008
Abstract: The dichloromethane and n-butanol extracts obtained from fresh bulbs of Hippeastrum vittatum (Amaryllidaceae), collected in Southern Brazil, were evaluated for their cytotoxic activity in vitro against five human cell lines (HT29 colon adenocarcinoma, H460 non-small cell lung carcinoma, RXF393 renal cell carcinoma, MCF7 breast cancer, and OVCAR3 epithelial ovarian cancer), using the sulphorhodamine B assay. Both extracts showed potential antiproliferative activity. From CH(2)Cl(2) fraction, three alkaloids were isolated: lycorine, vittatine and montanine. The two last compounds were submitted to the antiproliferative assay and the highest level of cytotoxicity was found for the alkaloid montanine.

Subjects :: Alkaloids chemistry
Antineoplastic Agents, Phytogenic chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Drug Screening Assays, Antitumor
Humans
Plant Extracts chemistry
Alkaloids pharmacology
Antineoplastic Agents, Phytogenic pharmacology
Liliaceae chemistry
Plant Extracts pharmacology

Language :: English
ISSN :: 1618-095X
Volume :: 15
Issue :: 10
Database :: MEDLINE
Journal :: Phytomedicine : international journal of phytotherapy and phytopharmacology
Publication Type :: Academic Journal
Accession number :: 18304791
Full Text :: https://doi.org/10.1016/j.phymed.2007.12.001

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