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Feasibility of dynamic 3-D color Doppler ultrasound for imaging penile vascular change in renal transplant patients with erectile dysfunction responding to sildenafil.
- Source :
-
Ultrasound in medicine & biology [Ultrasound Med Biol] 2008 Jun; Vol. 34 (6), pp. 885-91. Date of Electronic Publication: 2008 Mar 04. - Publication Year :
- 2008
-
Abstract
- Renal transplant recipients (RTRs) have a high incidence of erectile dysfunction (ED). Differentiation of penile vasculogenic impotence from other causes is important for treatment. Conventional 2-D color Doppler assessment after intracavernosal stimulant injection often fails to produce reliable results because of limited views by the cross-sectional imaging and the painful procedure. In comparison to the findings in three healthy volunteers, we determined cavernosal vascular hemodynamics in eight RTRs with ED before and after oral sildenafil by using live 3-D ultrasound and dynamic 3-D color Doppler. Results showed that, before sildenafil, penile arterial flow signals could only be reliably detected in one patient. After sildenafil, all had reliably detectable flow with grades II to III erection. Our data suggest that 3-D volumetric changes of the penis and its vasculature during erection can be studied by this technique and that this method could be useful for the evaluation of new drugs and therapeutic biofeedback.
- Subjects :
- Administration, Oral
Adult
Blood Flow Velocity
Erectile Dysfunction drug therapy
Erectile Dysfunction physiopathology
Feasibility Studies
Humans
Impotence, Vasculogenic complications
Impotence, Vasculogenic diagnostic imaging
Male
Middle Aged
Penis blood supply
Penis diagnostic imaging
Purines therapeutic use
Sildenafil Citrate
Treatment Outcome
Erectile Dysfunction diagnostic imaging
Imaging, Three-Dimensional
Kidney Transplantation
Piperazines therapeutic use
Sulfones therapeutic use
Ultrasonography, Doppler, Color methods
Vasodilator Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0301-5629
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Ultrasound in medicine & biology
- Publication Type :
- Academic Journal
- Accession number :
- 18295391
- Full Text :
- https://doi.org/10.1016/j.ultrasmedbio.2007.11.013