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CT colonography and computer-aided detection: effect of false-positive results on reader specificity and reading efficiency in a low-prevalence screening population.
- Source :
-
Radiology [Radiology] 2008 Apr; Vol. 247 (1), pp. 133-40. Date of Electronic Publication: 2008 Feb 21. - Publication Year :
- 2008
-
Abstract
- Purpose: To retrospectively evaluate the effect of increasing numbers of computer-aided detection (CAD)-generated false-positive (FP) marks on reader specificity and reporting times by using computed tomographic (CT) colonography in a low-prevalence screening population.<br />Materials and Methods: Ethics committee approval and informed consent were obtained for this HIPAA-compliant study. Four readers each read 48 data sets (26 men, 22 women; mean age, 57 years) from a screening population (three containing polyps) without CAD application, followed by review of the CAD output and recorded findings and diagnostic confidence. The 45 data sets that were designated as normal were chosen such that 22 generated 15 or fewer FP CAD marks and 23 generated more than 15 FP CAD marks. Sensitivity, specificity, and receiver operating characteristic (ROC) curves were calculated with and without CAD. The relationships between the number of CAD FP marks and reader confidence, reporting times, and correct data set classification were analyzed by using linear and logistic regression.<br />Results: Across all readers, CAD resulted in four additional FP detections. Overall reader sensitivity and specificity (6-mm polyp threshold) before and after CAD application were 0.75 (95% confidence interval [CI]: 0.43, 0.95) versus 0.83 (95% CI: 0.52, 0.98) and 0.96 (95% CI: 0.91, 0.98) versus 0.93 (95% CI: 0.88, 0.96), respectively. The area under the ROC curve increased from 0.57 (95% CI: 0.34, 0.80) to 0.61 (95% CI: 0.42, 0.80). There was no correlation between an increasing number of CAD FP marks and reader confidence (P = .71) or correct study classification (P = .23), but there was a positive correlation with CAD-assisted reading times (0.06 [95% CI: 0.02, 0.10], P = .002).<br />Conclusion: Increasing numbers of CAD FP marks did not adversely influence correct reader study classification or diagnostic confidence, although reporting times did increase.
- Subjects :
- Adenomatous Polyps diagnostic imaging
Adult
Aged
Aged, 80 and over
False Positive Reactions
Female
Humans
Male
Middle Aged
Observer Variation
ROC Curve
Sensitivity and Specificity
Colonic Polyps diagnostic imaging
Colonography, Computed Tomographic
Radiographic Image Interpretation, Computer-Assisted
Subjects
Details
- Language :
- English
- ISSN :
- 1527-1315
- Volume :
- 247
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 18292478
- Full Text :
- https://doi.org/10.1148/radiol.2471070816