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Differentiating the dementias. Revisiting synucleinopathies and tauopathies.
- Source :
-
Current Alzheimer research [Curr Alzheimer Res] 2008 Feb; Vol. 5 (1), pp. 52-60. - Publication Year :
- 2008
-
Abstract
- Dementia is a common, chronic and progressive illness. Many different types of dementia exist. It is important to have knowledge of the various dementia presentations so that the clinician can differentiate one type from another. Past and current approaches of classifying dementias are reviewed in this paper. The past cortical/subcortical scheme is reviewed as well as the current synucleinopathy/tauopathy scheme. This paper focuses on the most common synucleinopathies and tauopathies including Alzheimer's Dementia, Dementia with Lewy Bodies, Parkinson's Disease, Frontotemporal Dementia, Progressive Supranuclear Palsy, Multiple System Atrophy and Corticobasal Ganglionic Degeneration. We systematically approach each dementia and review cognitive, psychiatry and neurological features of each. We also compare and contrast each dementia and the synucleinopathies and taupoathies alike. Our goal is to provide the clinician with sufficient knowledge to competently and confidently diagnose a patient who presents with progressive cognitive decline and deterioration in functioning.
- Subjects :
- Dementia classification
Dementia complications
Dementia physiopathology
Diagnosis, Differential
Humans
Parkinson Disease complications
Parkinson Disease metabolism
Tauopathies diagnosis
Tauopathies metabolism
Tauopathies physiopathology
Dementia diagnosis
Parkinson Disease psychology
Synucleins metabolism
Tauopathies classification
tau Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1567-2050
- Volume :
- 5
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current Alzheimer research
- Publication Type :
- Academic Journal
- Accession number :
- 18288932
- Full Text :
- https://doi.org/10.2174/156720508783884657