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Splenomegaly and modified erythropoiesis in KLF13-/- mice.
- Source :
-
The Journal of biological chemistry [J Biol Chem] 2008 May 02; Vol. 283 (18), pp. 11897-904. Date of Electronic Publication: 2008 Feb 19. - Publication Year :
- 2008
-
Abstract
- To study the function of the Krüppel-like transcription factor KLF13 in vivo, we generated mice with a disrupted Klf13 allele. Although Klf13(-/-) mice are viable, fewer mice were present at 3 weeks than predicted by Mendelian inheritance. Viable Klf13(-/-) mice had reduced numbers of circulating erythrocytes and a larger spleen. The spleen contained an increased number of Ter119(med)CD71(hi), Ter119(hi)CD71(hi), and Ter119(hi)CD71(med) cells but not Ter119(hi)CD71(-) cells, indicating an increase in less mature erythroblasts. A higher proportion of the Ter119(med)CD71(hi) cells were proliferating, indicating that the mice were under a degree of erythropoietic stress. These data indicate that KLF13 is involved in the normal control of erythropoiesis.
- Subjects :
- Animals
Apoptosis genetics
Base Sequence
Blood Cell Count
Bone Marrow pathology
Cell Cycle Proteins genetics
Cell Differentiation
Cell Proliferation
Erythroblasts pathology
Gene Deletion
Gene Expression Regulation
Gene Targeting
Genotype
Kruppel-Like Transcription Factors genetics
Mice
Mice, Knockout
Molecular Sequence Data
Organ Size
RNA, Messenger genetics
RNA, Messenger metabolism
Repressor Proteins genetics
Splenomegaly pathology
Erythropoiesis
Kruppel-Like Transcription Factors deficiency
Splenomegaly physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9258
- Volume :
- 283
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- The Journal of biological chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18285334
- Full Text :
- https://doi.org/10.1074/jbc.M709569200