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Overview of emerging pharmacologic agents for acute heart failure syndromes.
- Source :
-
European journal of heart failure [Eur J Heart Fail] 2008 Feb; Vol. 10 (2), pp. 201-13. - Publication Year :
- 2008
-
Abstract
- Background: Several therapies commonly used for the treatment of acute heart failure syndromes (AHFS) present some well-known limitations and have been associated with an early increase in the risk of death. There is, therefore, an unmet need for new pharmacologic agents for the early management of AHFS that may improve both short- and long-term outcomes.<br />Aim: To review the recent evidence on emerging pharmacologic therapies in AHFS.<br />Methods: A systematic search of peer-reviewed publications was performed on MEDLINE, EMBASE and Clinical Trials.gov from January 1990 to August 2007. The results of unpublished or ongoing trials were obtained from presentations at national and international meetings and pharmaceutical industry releases. Bibliographies from these references were also reviewed, as were additional articles identified by content experts.<br />Results: Cumulative data from large studies and randomised trials suggest that therapies with innovative mechanisms of action may safely and effectively reduce pulmonary congestion or improve cardiac performance in AHFS patients.<br />Conclusion: Some investigational agents for the management of AHFS are able to improve haemodynamics and/or clinical status. In spite of these promising findings, no new agent has demonstrated a clear benefit in terms of long-term clinical outcomes compared to placebo or conventional therapies.
- Subjects :
- Adenosine antagonists & inhibitors
Cardiovascular Agents pharmacology
Cardiovascular Agents therapeutic use
Endothelin-1 antagonists & inhibitors
Etiocholanolone analogs & derivatives
Etiocholanolone therapeutic use
Heart Failure physiopathology
Hemodynamics
Humans
Hydrazones pharmacology
Hydrazones therapeutic use
Natriuretic Peptide, Brain therapeutic use
Perhexiline pharmacology
Perhexiline therapeutic use
Pyridazines pharmacology
Pyridazines therapeutic use
Randomized Controlled Trials as Topic
Simendan
Sodium-Potassium-Exchanging ATPase antagonists & inhibitors
Syndrome
Vasodilator Agents pharmacology
Vasodilator Agents therapeutic use
Heart Failure drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1388-9842
- Volume :
- 10
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of heart failure
- Publication Type :
- Academic Journal
- Accession number :
- 18279775
- Full Text :
- https://doi.org/10.1016/j.ejheart.2008.01.002