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Glucocorticoid excess affects cortical bone geometry in premenopausal, but not postmenopausal, women.
- Source :
-
Calcified tissue international [Calcif Tissue Int] 2008 Mar; Vol. 82 (3), pp. 182-90. Date of Electronic Publication: 2008 Feb 17. - Publication Year :
- 2008
-
Abstract
- Glucocorticoid (GC) excess causes a great increase in fracture risk, but the effects of GC excess on cortical bone geometry are unknown. The present study was performed to examine the effects of GC excess on cortical bone geometry in both premenopausal and postmenopausal women. Ninety-six women receiving oral GC treatments and 10 women with Cushing syndrome (CS) were each compared to age-matched control subjects using peripheral quantitative computed tomography. Total area, periosteal circumference, and polar strength strain index (SSIp) were significantly lower in GC-treated patients compared with control subjects in premenopausal women but not in postmenopausal women. Moreover, cortical area and thickness as well as periosteal circumference and SSIp were significantly lower in patients with CS compared to controls in premenopausal women but not in postmenopausal women. Total area, cortical area, cortical thickness, periosteal circumference, as well as SSIp were significantly lower in GC-treated patients with vertebral fractures compared to those without vertebral fractures in premenopausal women but not in postmenopausal women. In conclusion, endogenous or exogenous GC excess affects bone geometry of forearms of premenopausal, but not postmenopausal, women. These effects of GC excess on bone geometry may provide a strength loss mechanism beneath increased vertebral fracture risk.
- Subjects :
- Administration, Oral
Adult
Cushing Syndrome blood
Dose-Response Relationship, Drug
Female
Humans
Middle Aged
Osteoporosis, Postmenopausal blood
Osteoporosis, Postmenopausal complications
Osteoporosis, Postmenopausal diagnosis
Periosteum diagnostic imaging
Periosteum drug effects
Periosteum metabolism
Spinal Fractures blood
Spinal Fractures diagnosis
Spinal Fractures etiology
Spine diagnostic imaging
Tomography, X-Ray Computed
Ulna diagnostic imaging
Ulna metabolism
Cushing Syndrome drug therapy
Glucocorticoids adverse effects
Hydrocortisone blood
Postmenopause
Prednisolone adverse effects
Premenopause
Ulna drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0171-967X
- Volume :
- 82
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Calcified tissue international
- Publication Type :
- Academic Journal
- Accession number :
- 18278571
- Full Text :
- https://doi.org/10.1007/s00223-008-9106-9