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Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in hypertensive and normotensive patients with coronary artery disease.
- Source :
-
Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2008 Apr; Vol. 13 (2), pp. 153-6. - Publication Year :
- 2008
-
Abstract
- Aim: Hypertension is one of the risk factors for cardiovascular diseases. The kidneys could be a victim and/or culprit of hypertension. Recently, the value of neutrophil gelatinase-associated lipocalin (NGAL) was highlighted as a novel marker for early detection of acute renal damage. Therefore, the aim of the study was to assess whether hypertension could affect NGAL and cystatin C levels in patients with normal serum creatinine (lower than 1.5 mg/dL in males and 1.2 mg/dL in females) and stable coronary artery disease.<br />Methods: Serum, urinary NGAL, cystatin C and estimated glomerular filtration rate (eGFR; Modification of Diet in Renal Disease study (MDRD) and Cockcroft-Gault formulas) were evaluated in hypertensive, normotensive patients with stable coronary heart disease and healthy volunteers.<br />Results: Normotensives had significantly lower NGAL than hypertensives. Serum cystatin C was significantly lower in normotensives than in hypertensives. Urinary NGAL did not differ significantly between these groups. Despite similar serum creatinine levels, eGFR (MDRD and Cockcroft-Gault formulas) was significantly higher in normotensives than in hypertensives. Serum NGAL was related, in univariate analysis, to serum creatinine, urea, urinary NGAL, haemoglobin, haematocrit, duration of hypertension, age, eGFR by MDRD and Cockcroft-Gault, and cystatin C.<br />Conclusion: Hypertension is associated with kidney injury as reflected by elevated serum NGAL and cystatin C. It is noteworthy that despite normal serum creatinine, eGFR is relatively low suggesting impaired renal function. Therefore, NGAL needs to be investigated as a potential early marker for impaired kidney function/kidney injury, especially in patients with another risk factor for kidney damage, namely coronary artery disease.
- Subjects :
- Acute-Phase Proteins urine
Adult
Aged
Biomarkers blood
Coronary Artery Disease complications
Coronary Artery Disease physiopathology
Coronary Artery Disease urine
Creatinine blood
Cystatin C
Cystatins blood
Female
Glomerular Filtration Rate
Humans
Hypertension complications
Hypertension physiopathology
Hypertension urine
Kidney Diseases complications
Kidney Diseases physiopathology
Kidney Diseases urine
Lipocalin-2
Lipocalins urine
Male
Middle Aged
Pilot Projects
Proto-Oncogene Proteins urine
Reproducibility of Results
Up-Regulation
Coronary Artery Disease blood
Hypertension blood
Kidney Diseases blood
Lipocalins blood
Proto-Oncogene Proteins blood
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1797
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nephrology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 18275504
- Full Text :
- https://doi.org/10.1111/j.1440-1797.2007.00899.x