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Association study of the GAB2 gene with the risk of developing Alzheimer's disease.
- Source :
-
Neurobiology of disease [Neurobiol Dis] 2008 Apr; Vol. 30 (1), pp. 103-6. Date of Electronic Publication: 2008 Jan 05. - Publication Year :
- 2008
-
Abstract
- The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE varepsilon4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD cases) whatever the APOE status, even if we observed a slight tendency for an increase of the GG genotype (OR (GG versus GT+TT)=1.3, 95% CI 1.0-1.6, p=0.09) and the G allele frequency (OR=1.3, 95%CI 1.0-1.6, p=0.05) in varepsilon4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD.
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease pathology
Apolipoprotein E4 genetics
Brain pathology
Case-Control Studies
Chi-Square Distribution
Cross-Cultural Comparison
Female
Gene Frequency
Genotype
Humans
Male
Risk
Adaptor Proteins, Signal Transducing genetics
Alzheimer Disease genetics
Genetic Predisposition to Disease
Polymorphism, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1095-953X
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurobiology of disease
- Publication Type :
- Academic Journal
- Accession number :
- 18272374
- Full Text :
- https://doi.org/10.1016/j.nbd.2007.12.006