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Evaluation of glucose homeostasis.
- Source :
-
Current protocols in molecular biology [Curr Protoc Mol Biol] 2007 Jan; Vol. Chapter 29, pp. Unit 29B.3. - Publication Year :
- 2007
-
Abstract
- Obesity and dyslipidemia are often found in association with insulin resistance (IR). These components combined with hypertension characterize the most common endocrine disorder in humans, the metabolic syndrome. Thus, in addition to profiling body weight evolution and lipid metabolites, glucose tolerance (a reflection of IR) and insulin sensitivity should also be considered as part of any metabolic phenotyping protocol. The ability to measure IR and glucose tolerance is important not only in the quest to fully understand the pathogenesis of the metabolic syndrome in the mouse, but also to test the effects of potential interventions. This unit presents a variety of tests used for this purpose, including direct blood glucose measurements, insulin measurement by ELISA, the homeostatic model assessment, glucose tolerance and insulin sensitivity tests, and the euglycemic clamp.
- Subjects :
- Animals
Blood Glucose genetics
Glucose Clamp Technique instrumentation
Glucose Clamp Technique methods
Glucose Clamp Technique trends
Glucose Tolerance Test methods
Glucose Tolerance Test trends
Homeostasis genetics
Humans
Insulin administration & dosage
Mice
Models, Biological
Blood Glucose analysis
Blood Glucose physiology
Homeostasis physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1934-3647
- Volume :
- Chapter 29
- Database :
- MEDLINE
- Journal :
- Current protocols in molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 18265403
- Full Text :
- https://doi.org/10.1002/0471142727.mb29b03s77