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Proteomic approach to biomarker discovery in cancer tissue from lung adenocarcinoma among nonsmoking Chinese women in Hong Kong.
- Source :
-
Cancer investigation [Cancer Invest] 2008 Mar; Vol. 26 (2), pp. 128-35. - Publication Year :
- 2008
-
Abstract
- Half of the female patients with adenocarcinoma in East Asia are never-smokers. Proteomic analysis of tumor tissue may throw important light on the pathogenesis of this interesting subgroup of lung cancer. The cancer and adjacent normal lung tissue were taken from 21 never-smoked adenocarcinoma and profiled using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). Fifty-two proteins were significantly discriminatory between tumor and normal lung tissues. Ninety-three proteins were found to have high accuracy in discriminating between adenocarcinoma with or without smoking history. These proteins may yield new insights about the altered pathogenetic pathways of never-smoked lung cancers.
- Subjects :
- Adenocarcinoma ethnology
Adenocarcinoma pathology
Asian People ethnology
Carcinoma, Squamous Cell ethnology
Carcinoma, Squamous Cell pathology
Computational Biology
Female
Hong Kong epidemiology
Humans
Lung Neoplasms ethnology
Lung Neoplasms pathology
Male
Protein Array Analysis
Proteome analysis
Smoking
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Adenocarcinoma chemistry
Biomarkers, Tumor analysis
Carcinoma, Squamous Cell chemistry
Lung Neoplasms chemistry
Proteomics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-4192
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer investigation
- Publication Type :
- Academic Journal
- Accession number :
- 18259942
- Full Text :
- https://doi.org/10.1080/07357900701788031