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Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata.
- Source :
-
Journal of natural products [J Nat Prod] 2008 Mar; Vol. 71 (3), pp. 469-72. Date of Electronic Publication: 2008 Feb 08. - Publication Year :
- 2008
-
Abstract
- Three lipopeptides, ciliatamides A-C ( 1- 3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A ( 1) and B ( 2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antiprotozoal Agents chemistry
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Lipopeptides
Lipoproteins chemistry
Molecular Structure
Oceans and Seas
Oligopeptides chemistry
Antineoplastic Agents isolation & purification
Antineoplastic Agents pharmacology
Antiprotozoal Agents isolation & purification
Antiprotozoal Agents pharmacology
Leishmania drug effects
Lipoproteins isolation & purification
Lipoproteins pharmacology
Oligopeptides isolation & purification
Oligopeptides pharmacology
Porifera chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 71
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 18257536
- Full Text :
- https://doi.org/10.1021/np8000317