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Platelet inhibition by low-dose aspirin but not by clopidogrel reduces the axon-reflex current-induced vasodilation in humans.
- Source :
-
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2008 May; Vol. 294 (5), pp. R1420-6. Date of Electronic Publication: 2008 Feb 06. - Publication Year :
- 2008
-
Abstract
- We previously showed a prolonged inhibition of current-induced vasodilation (CIV) after a single oral high dose of aspirin. In this study, we tested the hypothesis of platelet involvement in CIV. Nine healthy volunteers took 75 mg aspirin/day, 98 mg of clopidogrel bisulfate/day, or placebo for 4 days. CIV was induced by two consecutive 1-min anodal current applications (0.08 mA/cm(2)) through deionized water with a 10-min interval. CIV was measured with laser Doppler flowmetry and expressed as a percentage of baseline cutaneous vascular conductance: %C(b). In a second experiment in 10 volunteers, aspirin and placebo were given as in experiment 1, but a 26-h delay from the last aspirin intake elapsed before ACh iontophoresis and postocclusive hyperemia were studied in parallel to CIV. In experiment 1, the means +/- SE amplitude of CIV was 822 +/- 314, 313 +/- 144, and 746 +/- 397%C(b) with placebo, aspirin (P < 0.05 from placebo and clopidogrel), and clopidogrel (NS from placebo), respectively. In experiment 2, CIV impairment with aspirin was confirmed: CIV amplitudes were 300 +/- 99, and 916 +/- 528%C(b) under aspirin and placebo, respectively (P < 0.05), whereas vasodilation to ACh iontophoresis (322 +/- 74 and 365 +/- 104%C(b)) and peak postocclusive hyperemia (491 +/- 137 and 661 +/- 248%C(b)) were not different between aspirin and placebo, respectively. Low-dose aspirin, even 26 h after oral administration, impairs CIV, while ACh-mediated vasodilation and postocclusive hyperemia are preserved. If platelets are involved in the neurovascular mechanism triggered by galvanic current application in humans, it is likely to occur through the cyclooxygenase but not the ADP pathway.
- Subjects :
- Acetylcholine pharmacology
Adenosine Diphosphate physiology
Adult
Axons drug effects
Blood Platelets drug effects
Blood Platelets enzymology
Blood Platelets metabolism
Clopidogrel
Electric Stimulation
Endothelium, Vascular drug effects
Endothelium, Vascular physiology
Female
Humans
Iontophoresis
Laser-Doppler Flowmetry
Male
Platelet Aggregation drug effects
Prostaglandin-Endoperoxide Synthases metabolism
Signal Transduction drug effects
Ticlopidine pharmacology
Vasodilator Agents pharmacology
Aspirin pharmacology
Axons physiology
Platelet Aggregation Inhibitors pharmacology
Ticlopidine analogs & derivatives
Vasodilation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6119
- Volume :
- 294
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Regulatory, integrative and comparative physiology
- Publication Type :
- Academic Journal
- Accession number :
- 18256140
- Full Text :
- https://doi.org/10.1152/ajpregu.00810.2007