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Suppressive effects of dehydroepiandrosterone and 3 beta-methyl-androst-5-en-17-one on attack towards lactating female intruders by castrated male mice. II. Brain neurosteroids.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1991 Jan 31; Vol. 174 (2), pp. 892-7. - Publication Year :
- 1991
-
Abstract
- Dehydroepiandrosterone (DHA) and 3 beta-methyl-androst-5-en-17-one (CH3-DHA) suppress attacks by castrated male mice towards lactating female intruders (Haug et al. Physiol. Behav. 46:955, 1989). Their effects on the concentrations of DHA, pregnenolone (delta 5P), and their sulfate ester (S) have been investigated in the brain of control and treated mice. A more than 2 fold, significant, decrease of delta 5P-S was the only change common to both steroids. DHA and CH3-DHA effects might be related to the antagonistic action of delta 5P-S on GABAA receptors.
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 174
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 1825169
- Full Text :
- https://doi.org/10.1016/0006-291x(91)91501-3