Back to Search
Start Over
Design and synthesis of trans 2-(furan-2-yl)vinyl heteroaromatic iodides with antitumour activity.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 Apr 01; Vol. 16 (7), pp. 4150-9. Date of Electronic Publication: 2007 Dec 25. - Publication Year :
- 2008
-
Abstract
- A new molecular modelling approach based on physico-chemical and pharmacokinetic properties, called Volsurf plus, was used to design new heterocyclic compounds with antiproliferative activity. The synthesis and in vitro antitumour tests on a breast carcinoma cell line (MCF7) confirmed VOLSURF predicted activity values.
- Subjects :
- Antineoplastic Agents chemistry
Cell Line, Tumor
Cell Survival drug effects
Drug Design
Humans
Iodides chemistry
Models, Molecular
Molecular Structure
Structure-Activity Relationship
Vinyl Compounds chemistry
Antineoplastic Agents chemical synthesis
Antineoplastic Agents pharmacology
Furans chemistry
Iodides chemical synthesis
Iodides pharmacology
Vinyl Compounds chemical synthesis
Vinyl Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 16
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18248996
- Full Text :
- https://doi.org/10.1016/j.bmc.2007.12.042