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Entry into a new class of protein kinase inhibitors by pseudo ring design.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Feb 01; Vol. 18 (3), pp. 897-900. Date of Electronic Publication: 2008 Jan 14. - Publication Year :
- 2008
-
Abstract
- A pyrimidin-4-yl-urea motif forming a pseudo ring by intramolecular hydrogen bonding has been designed to mimic the pyrido[2,3-d]pyrimidin-7-one core structure of a well-established class of protein kinase inhibitors. Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.
- Subjects :
- Amino Acids chemistry
Amino Acids pharmacology
Molecular Conformation
Molecular Mimicry
Molecular Structure
Protein Kinase Inhibitors chemistry
Pyrimidines chemistry
Structure-Activity Relationship
Urea chemistry
Drug Design
Models, Molecular
Protein Kinase Inhibitors chemical synthesis
Protein Kinase Inhibitors pharmacology
Pyridones chemistry
Pyridones pharmacology
Pyrimidines chemical synthesis
Pyrimidines pharmacology
Urea analogs & derivatives
Urea chemical synthesis
Urea pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18248988
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.12.041