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The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2008 Oct; Vol. 43 (10), pp. 2268-71. Date of Electronic Publication: 2007 Dec 27. - Publication Year :
- 2008
-
Abstract
- A successful synthesis of fukiic acid is described in 7% overall yield (6 steps from veratraldehyde). rac-Fukiic acid was found to be a potent inhibitor of HIV-1 integrase but did not reveal any antiviral activity in the MT-4 cells assay.
- Subjects :
- Animals
Base Sequence
Cattle
Cell Line
HIV Integrase Inhibitors chemistry
Humans
Phenylpropionates chemistry
Succinates chemistry
HIV Integrase metabolism
HIV Integrase Inhibitors chemical synthesis
HIV Integrase Inhibitors pharmacology
Phenylpropionates chemical synthesis
Phenylpropionates pharmacology
Succinates chemical synthesis
Succinates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0223-5234
- Volume :
- 43
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18243421
- Full Text :
- https://doi.org/10.1016/j.ejmech.2007.12.013