Back to Search
Start Over
Effects of vertical HIV infection on the persistence of anti-HBs after a schedule of three doses of recombinant hepatitis B vaccine.
- Source :
-
Vaccine [Vaccine] 2008 Feb 20; Vol. 26 (8), pp. 1032-7. Date of Electronic Publication: 2008 Jan 07. - Publication Year :
- 2008
-
Abstract
- Anti-HBs persistence following HBV vaccination among HIV-positive children has never been systematically studied in central Brazil. An historical cohort study was performed aiming to evaluate persistence of anti-HBs in HIV-positive children in comparison with an HIV-negative child group. Fifty-eight HIV-positive and 116 HIV-negative individuals were enrolled. Birth weight, breast-feeding duration, and the time elapsed since the last hepatitis B vaccine doses were similar between the groups. Fourteen (24%) out of 58 HIV-positive participants were anti-HBs positive and 101 (87%) out of 116 were HIV-negative (p<0.001). Among anti-HBs-positive individuals, the geometric mean titres were 118 and 298 mIU/mL, respectively to HIV-positive and HIV-negative groups (p=0.04). These results disclose a worrying picture regarding the failure of standard HBV vaccination among Brazilian HIV-infected children.
Details
- Language :
- English
- ISSN :
- 0264-410X
- Volume :
- 26
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 18242796
- Full Text :
- https://doi.org/10.1016/j.vaccine.2007.12.020