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Catechol-O-methyltransferase (COMT) val158met genotype is associated with BOLD response as a function of task characteristic.
- Source :
-
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2008 Dec; Vol. 33 (13), pp. 3046-57. Date of Electronic Publication: 2008 Jan 30. - Publication Year :
- 2008
-
Abstract
- The catechol-O-methyltransferase (COMT) val(158)met single nucleotide polymorphism (rs4680) has been shown to be associated with brain activation during a number of neurocognitive and emotional tasks. The present study evaluated genotypic associations with brain function during measurement of cognitive stability (prosaccades) and plasticity (antisaccades). A total of 36 healthy volunteers were genotyped for rs4680 and underwent functional magnetic resonance imaging (fMRI) at 1.5 T. Individuals with at least one val(158) allele (val(158) carriers, N=24) showed lower blood oxygen level-dependent (BOLD) response in ventromedial and dorsomedial prefrontal cortex during antisaccades compared to val(158) noncarriers, whereas met(158) homozygotes (N=12) showed lower BOLD response in a cluster in the posterior cingulate and precuneus during prosaccades compared to val(158) carriers. These findings suggest that associations of COMT val(158)met genotype with brain function may be mediated by task characteristics. The findings may be compatible with a hypothesis on the role of COMT val(158)met genotype in tonic and phasic dopamine levels in brain and differential effects on cognitive measures of stability (eg prosaccades) and plasticity (eg antisaccades).
- Subjects :
- Adult
Amino Acid Substitution genetics
Brain anatomy & histology
Brain Mapping
Female
Genetic Testing
Genotype
Humans
Magnetic Resonance Imaging
Male
Methionine genetics
Neuronal Plasticity genetics
Neuropsychological Tests
Photic Stimulation
Prefrontal Cortex anatomy & histology
Prefrontal Cortex enzymology
Valine genetics
Young Adult
Brain enzymology
Catechol O-Methyltransferase genetics
Cognition physiology
Dopamine metabolism
Polymorphism, Genetic genetics
Saccades genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1740-634X
- Volume :
- 33
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 18235427
- Full Text :
- https://doi.org/10.1038/sj.npp.1301658