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Local neuroretinal function during acute hypoxia in healthy older people.
- Source :
-
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2008 Feb; Vol. 49 (2), pp. 807-13. - Publication Year :
- 2008
-
Abstract
- Purpose: To measure the effect of acute, mild, systemic hypoxia on neuroretinal function in two different age groups.<br />Methods: The slow-flash paradigm of the multifocal electroretinogram (mfERG) was measured in two different oxygenation levels. Twelve participants of two age groups (28 +/- 4 and 55 +/- 5 years) breathed room air (normoxia) or 12% oxygen (hypoxia).<br />Results: During normoxia (SaO(2) = 98%) there was a significantly different effect between the younger and older participants on the mfERG positive waveform components (N1P1 amplitudes and P1 implicit times; P < 0.001). Hypoxia (SaO(2) = 90%) significantly decreased N1P1 response density amplitudes in the central retinal field in both groups, with a larger effect in the older group (P < 0.001). There was no significant change in function of the cellular generators of oscillatory potentials (OPs).<br />Conclusion: The results extend recent findings by showing a greater effect of hypoxia on ON- and OFF-bipolar cell function in healthy older persons than in younger persons, but no effect on OPs during moderate acute hypoxia in either age group.
Details
- Language :
- English
- ISSN :
- 0146-0404
- Volume :
- 49
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Investigative ophthalmology & visual science
- Publication Type :
- Academic Journal
- Accession number :
- 18235031
- Full Text :
- https://doi.org/10.1167/iovs.07-0994