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Different growth patterns of non-small cell lung cancer represent distinct biologic subtypes.
- Source :
-
The Annals of thoracic surgery [Ann Thorac Surg] 2008 Feb; Vol. 85 (2), pp. 395-405. - Publication Year :
- 2008
-
Abstract
- Background: We have recently shown the prognostic value of growth pattern classification in non-small cell lung cancer. The aim of this study is to validate the hypothesis that these growth patterns have a distinct angiogenic and proliferative profile.<br />Methods: Hematoxylin-eosin stained tissue sections of 239 patients with non-small cell lung cancer were classified into growth patterns. One representative tissue section per patient was double immunostained with CD34 and Ki-67 antibodies. Endothelial cell proliferation fraction, tumor cell proliferation fraction, microvessel density, and Chalkley count were assessed at the invading front and the center of the selected tumor section.<br />Results: According to the growth pattern classification, 161 patients (67.4%) had a destructive, 33 (13.8%) a papillary, and 45 (18.8%) an alveolar growth pattern. There were significant differences in endothelial cell proliferation fraction (p < 0.001), tumor cell proliferation fraction (p < 0.001), microvessel density (p < 0.001), and Chalkley count (p < 0.001) between the growth patterns. Multiple Cox regression analysis showed that a low endothelial cell proliferation fraction was consistently an independent prognostic factor for overall poor (hazard ratio = 0.93; confidence interval: 0.88 to 0.97, p = 0.002) and disease-free survival (hazard ratio = 0.94; confidence interval: 0.89 to 0.98, p = 0.007).<br />Conclusions: Growth patterns have a distinct angiogenic and proliferative profile. In non-small cell lung cancer, a low degree of angiogenesis (a low endothelial cell proliferation fraction) is associated with poor prognosis.
- Subjects :
- Adult
Aged
Biopsy, Needle
Carcinoma, Non-Small-Cell Lung mortality
Carcinoma, Non-Small-Cell Lung therapy
Cell Growth Processes physiology
Cohort Studies
Disease-Free Survival
Female
Humans
Immunohistochemistry
Lung Neoplasms mortality
Lung Neoplasms therapy
Male
Middle Aged
Neoplasm Recurrence, Local mortality
Neovascularization, Pathologic physiopathology
Probability
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Sensitivity and Specificity
Statistics, Nonparametric
Survival Analysis
Carcinoma, Non-Small-Cell Lung pathology
Cell Proliferation
Lung Neoplasms pathology
Neoplasm Invasiveness pathology
Neoplasm Recurrence, Local pathology
Neovascularization, Pathologic pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1552-6259
- Volume :
- 85
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Annals of thoracic surgery
- Publication Type :
- Academic Journal
- Accession number :
- 18222232
- Full Text :
- https://doi.org/10.1016/j.athoracsur.2007.08.054