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Dickkopf-3 as a new potential marker for neoangiogenesis in colorectal cancer: expression in cancer tissue and adjacent non-cancerous tissue.
- Source :
-
Disease markers [Dis Markers] 2008; Vol. 24 (2), pp. 101-9. - Publication Year :
- 2008
-
Abstract
- Gene expression of Dickkopf-3 (Dkk-3) has been shown to be upregulated in tumor endothelium of colorectal cancer (CRC). For the first time, we analyzed Dkk-3 protein expression in CRC and its potential as a marker for neoangiogenesis. We used tissue microarrays (TMAs) to investigate Dkk-3 in microvessels of 403 CRC samples, 318 appropriate adjacent non-cancerous samples and 127 normal colorectal samples. Of cancer samples with CD31-positive microvessels, 67.7% were positive for Dkk-3. Dkk-3 staining was demonstrated in endothelial cells of all microvessels in nearly all cases. Dkk-3-positive samples showed a higher mean microvessel count than did Dkk-3-negative samples (P=0.001). Dkk-3 expression increased with rising numbers of microvessels per sample (P<0.0001). In adjacent samples with CD31-positive microvessels, 56% were Dkk-3-positive in all microvessels. Similar to cancer samples, Dkk-3-positive adjacent samples had a higher mean microvessel count than did Dkk-3-negative samples (P<0.0001), and Dkk-3 expression also increased with rising numbers of microvessels (P<0.0001). All microvessels in normal mucosa samples were negative for Dkk-3. Dkk-3 can be considered a putative pro-angiogenic protein in neovascularization and may possibly be a marker for neoangiogenesis in CRC. Further investigations will elucidate whether Dkk-3 is a target structure for novel therapies.
- Subjects :
- Adaptor Proteins, Signal Transducing
Aged
Chemokines
Colon chemistry
Female
Humans
Male
Middle Aged
Rectum chemistry
Biomarkers, Tumor analysis
Colorectal Neoplasms blood supply
Intercellular Signaling Peptides and Proteins analysis
Intestinal Mucosa chemistry
Neovascularization, Pathologic diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0278-0240
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Disease markers
- Publication Type :
- Academic Journal
- Accession number :
- 18219095
- Full Text :
- https://doi.org/10.1155/2008/160907