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Combination echinocandin-polyene treatment of murine mucormycosis.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2008 Apr; Vol. 52 (4), pp. 1556-8. Date of Electronic Publication: 2008 Jan 22. - Publication Year :
- 2008
-
Abstract
- We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.
- Subjects :
- Amphotericin B administration & dosage
Amphotericin B therapeutic use
Anidulafungin
Animals
Disease Models, Animal
Drug Therapy, Combination
Humans
Lipopeptides
Lipoproteins administration & dosage
Lipoproteins therapeutic use
Liposomes administration & dosage
Liposomes therapeutic use
Male
Micafungin
Mice
Mice, Inbred BALB C
Mucormycosis microbiology
Rhizopus classification
Treatment Outcome
Antifungal Agents administration & dosage
Antifungal Agents therapeutic use
Echinocandins administration & dosage
Echinocandins therapeutic use
Mucormycosis drug therapy
Polyenes administration & dosage
Polyenes therapeutic use
Rhizopus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 52
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 18212099
- Full Text :
- https://doi.org/10.1128/AAC.01458-07