GAX-collagen in the human vocal fold.

A report is presented of the first histological study of GAX-collagen injected into the human vocal cord. The study concerns a specimen from an arytenoidectomy performed 28 months after injection. As it had already been the case in the animal, the excellent integration of GAX-collagen with the host-tissues has been noted, as well as the stability of the result more than 2 years later. It also appeared that colonization of GAX-collagen by the host cells is less rapid than for the ZCI. While inflammatory reaction is weak in the region of the GAX-collagen, there is to be seen some atrophy and fibrosis of the muscular fibres around the deposit, probably due to compression during injection.