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Chemotherapy followed by syngeneic dendritic cell injection in the mouse: findings and implications for human treatment.
- Source :
-
Urology [Urology] 2007 Dec; Vol. 70 (6 Suppl), pp. 36-41. - Publication Year :
- 2007
-
Abstract
- A growing number of studies have described an apparent synergy between systemic chemotherapy administration and the intratumoral injection of dendritic cells (DCs) in the successful treatment of murine tumors. A review of several of these studies is undertaken here and possible combinations of DC therapy and conventional cancer therapies are discussed with the goal of contemplating the exploitation of current findings and theory toward the treatment of human patients with cancer. The methods and results of several murine studies are described in detail and additional reference is made to other relevant murine studies. Hypothetical routes of synergy between DC therapy, chemotherapy, and ablative therapies are explored, and the potentially significant role played by the regulatory immune system is discussed. Given the results of preclinical studies and the current understanding of cancer immunity, it is possible to consider a human treatment that calls for focal ablation of cancer followed by intratumoral DC injection, in the setting of chemotherapy-based regulatory T-cell depletion.
- Subjects :
- Animals
Combined Modality Therapy methods
Disease Models, Animal
Humans
Immune System
Immunotherapy methods
Mice
Neoplasms immunology
T-Lymphocytes metabolism
Antineoplastic Agents pharmacology
Cell Transplantation methods
Dendritic Cells cytology
Medical Oncology methods
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1527-9995
- Volume :
- 70
- Issue :
- 6 Suppl
- Database :
- MEDLINE
- Journal :
- Urology
- Publication Type :
- Academic Journal
- Accession number :
- 18194710
- Full Text :
- https://doi.org/10.1016/j.urology.2007.06.1127