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Primary acinar cell carcinoma of the liver.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2008 Mar; Vol. 452 (3), pp. 337-41. - Publication Year :
- 2008
-
Abstract
- We report a case of acinar cell carcinoma primary to the liver. The tumor was diagnosed in a 35-year-old woman complaining of abdominal pain and asthenia; serum alpha-fetoprotein (AFP) levels were increased at 6,000 IU/mL; imaging studies showed a hypervascular mass located in the left lobe of the liver. A left lobectomy was performed. The tumor had a heterogeneous appearance. In well-differentiated areas, tumor cells formed acinar structures, had a pyramidal shape and a highly eosinophilic, granular cytoplasm, PAS diastase resistant. In less-differentiated areas, tumor cells were endocrinelike. The immunohistochemical study showed that tumor cells expressed trypsin. Alpha-fetoprotein and alphal-antritrypsin were detected in about 30% of cells; HepPar1 was present in 15% of cells. Chromogranin A and synaptophysin were detected in rare cells. After surgery, serum AFP levels quickly returned to normal; no evidence of recurrence or metastasis was observed during follow-up. The final diagnosis, based on histological, immunohistochemical, and ultrastructural arguments, was extra-pancreatic acinar cell carcinoma, primary to the liver. This unusual lesion is likely to be the result of an abnormal differentiation pathway involving a transformed multipotential progenitor cell.
- Subjects :
- Adult
Carcinoma, Acinar Cell metabolism
Carcinoma, Acinar Cell surgery
Female
Humans
Immunohistochemistry
Liver chemistry
Liver surgery
Liver Neoplasms metabolism
Liver Neoplasms surgery
Treatment Outcome
alpha 1-Antitrypsin analysis
alpha-Fetoproteins analysis
Carcinoma, Acinar Cell pathology
Liver pathology
Liver Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0945-6317
- Volume :
- 452
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 18193278
- Full Text :
- https://doi.org/10.1007/s00428-007-0556-7