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Bacopa monniera exerts antiamnesic effect on diazepam-induced anterograde amnesia in mice.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 2008 Sep; Vol. 200 (1), pp. 27-37. Date of Electronic Publication: 2008 Jan 13. - Publication Year :
- 2008
-
Abstract
- Rationale: As Benzodiazepines are known to produce amnesia by involvement of the GABAergic system, we examined Bacopa monniera, an herb known for memory enhancement for reversal of memory deficits caused by diazepam.<br />Objectives: The objective of the study was to study the effect of standardized extract of B. monniera on diazepam-induced amnesia in mice using Morris water maze.<br />Materials and Methods: We used the rota rod test as a screening measure for muscle incoordination followed by the Morris water maze scale to evaluate the effect of B. monniera on amnesia. The index of acquisition and retrieval was recorded with varying doses of Bacopa.<br />Results: The results revealed antiamnesic effects of B. monniera (120 mg kg(-1) oral) on diazepam (1.75 mg kg(-1) intraperitoneal)-induced amnesia. The degree of reversal by Bacopa was significant as it progressively reduced escape latency time when mice treated with diazepam were subjected to acquisition trials.<br />Conclusions: The antiamnesic effects of Bacopa suggest likely a gamma-aminobutyric acid-benzodiazepine pathway possibly affecting long-term potentiation.
- Subjects :
- Amnesia, Anterograde chemically induced
Animals
Anti-Anxiety Agents toxicity
Diazepam toxicity
Dose-Response Relationship, Drug
Male
Maze Learning drug effects
Mice
Plant Extracts administration & dosage
Psychomotor Performance drug effects
Receptors, GABA-A metabolism
Amnesia, Anterograde drug therapy
Bacopa chemistry
Plant Extracts pharmacology
Receptors, GABA-A drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0033-3158
- Volume :
- 200
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 18193203
- Full Text :
- https://doi.org/10.1007/s00213-007-1049-8