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Three-dimensional conformal or stereotactic reirradiation of recurrent, metastatic or new primary tumors. Analysis of 108 patients.
- Source :
-
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2008 Jan; Vol. 184 (1), pp. 36-40. - Publication Year :
- 2008
-
Abstract
- Purpose: To analyze the outcome of reirradiation of recurrent/metastatic or new primary tumors with three-dimensional conformal (3D-CRT) or stereotactic (SRT) techniques.<br />Patients and Methods: 108 patients reirradiated between 01/2002 and 01/2005 at the European Institute of Oncology, Milan, Italy, were analyzed. Primary diagnosis included breast, lung, head/neck, urologic tumors, and other primaries. Curative and palliative intent were applied to 27 (25%) and 81 patients (75%), respectively. 3D-CRT and SRT were employed in 57 (53%) and 48 patients (44%), respectively, up to a mean dose of 23 Gy.<br />Results: Median follow-up was 7 months (range, 1-50 months). Response, stabilization, and progression were observed in 33%, 36%, and 17% of patients, respectively (15 patients were not evaluable). No severe toxicity was reported. Median overall survival amounted to 32.6 months and was longer in patients treated with curative intent.<br />Conclusion: A small portion of patients can be cured with a second course of radiotherapy, and in many cases, palliation can be obtained. Low toxicity of reirradiation with use of modern techniques should allow for the delivery of higher doses and, in consequence, lead to an improvement in reirradiation outcome.
- Subjects :
- Adult
Aged
Aged, 80 and over
Disease Progression
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasm Recurrence, Local mortality
Neoplasms, Radiation-Induced mortality
Neoplasms, Second Primary mortality
Palliative Care
Retreatment
Survival Rate
Lymphatic Metastasis radiotherapy
Neoplasm Recurrence, Local radiotherapy
Neoplasms, Radiation-Induced radiotherapy
Neoplasms, Second Primary radiotherapy
Radiosurgery methods
Radiotherapy Planning, Computer-Assisted methods
Radiotherapy, Conformal methods
Subjects
Details
- Language :
- English
- ISSN :
- 0179-7158
- Volume :
- 184
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
- Publication Type :
- Academic Journal
- Accession number :
- 18188521
- Full Text :
- https://doi.org/10.1007/s00066-008-1783-9