Back to Search
Start Over
Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation.
- Source :
-
Journal of molecular neuroscience : MN [J Mol Neurosci] 2008 Feb; Vol. 34 (2), pp. 165-71. Date of Electronic Publication: 2008 Jan 05. - Publication Year :
- 2008
-
Abstract
- One of the neuropathological features of Alzheimer's disease (AD) is the deposition of senile plaques containing beta-amyloid (A beta). There is limited evidence for the treatment to arrest A beta pathology of AD. In our present study, we tested the effect of coenzyme Q10 (CoQ10), an endogenous antioxidant and a powerful free radical scavenger, on A beta in the aged transgenic mice overexpressing Alzheimer presenilin 1-L235P (leucine-to-proline mutation at codon 235, 16-17 months old). The treatment by feeding the transgenic mice with CoQ10 for 60 days (1,200 mg kg(-1) day(-1)) partially attenuated A beta overproduction and intracellular A beta deposit in the cortex of the transgenic mice compared with the age-matched untreated transgenic mice. Meanwhile, an increased oxidative stress reaction was detected as evidenced by elevated level of malondialdehyde (MDA) and decreased activity of superoxide dismutase (SOD) in the transgenic mice relative to the wild-type mice, and supplementation of CoQ10 partially decreased MDA level and upregulated the activity of SOD. The results indicate that oxidative stress is enhanced in the brain of the transgenic mice, that this enhancement may further promote A beta 42 overproduction in a vicious formation, and that CoQ10 would be beneficial for the therapy of AD.
- Subjects :
- Aged
Alzheimer Disease metabolism
Animals
Cerebral Cortex cytology
Cerebral Cortex metabolism
Coenzymes metabolism
Female
Humans
Malondialdehyde metabolism
Mice
Mice, Transgenic
Oxidative Stress
Plaque, Amyloid pathology
Point Mutation
Presenilin-1 metabolism
Superoxide Dismutase metabolism
Ubiquinone metabolism
Alzheimer Disease genetics
Alzheimer Disease pathology
Amyloid beta-Peptides metabolism
Peptide Fragments metabolism
Presenilin-1 genetics
Ubiquinone analogs & derivatives
Vitamins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0895-8696
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of molecular neuroscience : MN
- Publication Type :
- Academic Journal
- Accession number :
- 18181031
- Full Text :
- https://doi.org/10.1007/s12031-007-9033-7