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Induction of the carrier state in pigeons infected with Salmonella enterica subspecies enterica serovar typhimurium PT99 by treatment with florfenicol: a matter of pharmacokinetics.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2008 Mar; Vol. 52 (3), pp. 954-61. Date of Electronic Publication: 2008 Jan 07. - Publication Year :
- 2008
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Abstract
- Paratyphoid caused by Salmonella enterica subsp. enterica serovar Typhimurium is the main bacterial disease in pigeons. The ability of Salmonella serovar Typhimurium to persist intracellularly inside pigeon macrophages results in the development of chronic carriers, which maintain the infection in the flock. In this study, the effect of drinking-water medication with florfenicol on Salmonella infection in pigeons was examined. The pharmacokinetics of florfenicol in pigeons revealed a relatively high volume of distribution of 2.02 liters/kg of body weight and maximum concentrations in plasma higher than the MICs for the Salmonella strain used (4 microg/ml) but quick clearance of florfenicol due to a short half-life of 1.73 h. Together with highly variable bioavailability and erratic drinking-water uptake, these parameters resulted in the inability to reach a steady-state concentration through the continuous administration of florfenicol in the drinking water. Florfenicol was capable of reducing only moderately the number of intracellular salmonellae in infected pigeon macrophages in vitro. Only at high extracellular concentrations (>16 microg/ml) was a more-than-10-fold reduction of the number of intracellular bacteria noticed. Florfenicol treatment of pigeons via the drinking water from 2 days after experimental inoculation with Salmonella serovar Typhimurium until euthanasia at 16 days postinoculation resulted in a reduction of Salmonella shedding and an improvement in the fecal consistency. However, internal organs in florfenicol-treated pigeons were significantly more heavily colonized than those in untreated pigeons. In conclusion, the oral application of florfenicol for the treatment of pigeon paratyphoid contributes to the development of carrier animals through sub-MIC concentrations in plasma that do not inhibit intracellular persistency.
- Subjects :
- Animals
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents therapeutic use
Carrier State microbiology
Feces microbiology
Macrophages microbiology
Microbial Sensitivity Tests statistics & numerical data
Salmonella Infections, Animal microbiology
Salmonella typhimurium drug effects
Salmonella typhimurium pathogenicity
Thiamphenicol administration & dosage
Thiamphenicol pharmacokinetics
Thiamphenicol pharmacology
Thiamphenicol therapeutic use
Anti-Bacterial Agents pharmacokinetics
Carrier State drug therapy
Columbidae microbiology
Salmonella Infections, Animal drug therapy
Salmonella typhimurium isolation & purification
Thiamphenicol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 52
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 18180355
- Full Text :
- https://doi.org/10.1128/AAC.00575-07