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A sexually dimorphic distribution pattern of the novel estrogen receptor G-protein-coupled receptor 30 in some brain areas of the hamster.
A sexually dimorphic distribution pattern of the novel estrogen receptor G-protein-coupled receptor 30 in some brain areas of the hamster.
- Source :
-
The Journal of endocrinology [J Endocrinol] 2008 Jan; Vol. 196 (1), pp. 131-8. - Publication Year :
- 2008
-
Abstract
- The isolation of the G-protein-coupled receptor 30 (GPR30), an orphan membrane receptor unrelated to nuclear estrogen receptors (ERs), has become a key factor towards the unraveling of rapid estrogen action. This membrane receptor together with cellular signaling intermediaries, i.e., extracellular signal-dependent kinases 1 and 2, may promote neuronal proliferation and differentiation activities. In the present study, an evident gene expression pattern of GPR30 characterized postnatal 7 (young) and 60 (adult) days of age hamsters as shown by its heterogeneous mRNA distribution in hypothalamic, amygdalar and cerebellar areas of both sexes. In particular, most of the brain areas considered in the adult hamster plus only the amygdala and cerebellum of young animals behaved in a sexually dimorphic fashion. This similar pattern was also detected for the ERalpha and beta, as shown by the latter receptor prevailing in young and adult females, while the former predominated in young females. Even for the two kinases, a sexually dimorphic distribution was featured above all for young hamsters. Overall, the findings of the present study established a distinct expression pattern of the novel ER (GPR30) that may operate differently in some brain areas of the hamster and this may provide interesting insights regarding its probable neuroprotective role during the execution of some hibernating states, which are typical of our rodent model.
- Subjects :
- Aging
Amygdala chemistry
Animals
Cerebellum chemistry
Cricetinae
Estrogen Receptor alpha analysis
Estrogen Receptor alpha genetics
Estrogen Receptor beta analysis
Estrogen Receptor beta genetics
Female
Gene Expression
Hypothalamus chemistry
Male
Mesocricetus
Mitogen-Activated Protein Kinase 1 analysis
Mitogen-Activated Protein Kinase 3 analysis
RNA, Messenger analysis
Receptors, G-Protein-Coupled genetics
Reverse Transcriptase Polymerase Chain Reaction
Tissue Distribution
Brain Chemistry
Receptors, Estrogen analysis
Receptors, G-Protein-Coupled analysis
Sex Characteristics
Subjects
Details
- Language :
- English
- ISSN :
- 1479-6805
- Volume :
- 196
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 18180324
- Full Text :
- https://doi.org/10.1677/JOE-07-0392